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The World Health Organization (WHO) Recommends Vaccine Composition for the 2011-2012 Northern Hemisphere Influenza Season
PandemicFlu.gov - 2 hours 59 min ago
The World Health Organization (WHO) Recommends Vaccine Composition for the 2011-2012 Northern Hemisphere Influenza Season
Categories: Government Agency News
Effect of hurricane katrina on incidence of acute myocardial infarction in new orleans three years after the storm
Environmental/Disaster News - 14 hours 59 min ago
The American Journal of Cardiology
5 US urban counties lead ‘terror hot spots’ list
Homeland Security News - Tue, 02/07/2012 - 12:13
Nearly a third of all terrorist attacks on American soil from 1970 to 2008 occurred in just five metropolitan US counties, according to a new study which says that 65 of the nation’s 3,143 counties were “hot spots’ of terrorism. According to a study by the University of Maryland researchers, sponsored by the US Department [...]
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5 US urban counties lead ‘terror hot spots’ list
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Lone wolf terror threat warning
Homeland Security News - Tue, 02/07/2012 - 12:10
The UK could face a growing threat from “lone wolf” terrorists returning from fighting overseas in the next few years, a think tank has warned. The Royal United Services Institute estimates about 50 Britons are fighting with Somali extremists al-Shabab. Returnees from “wars in Somalia, Yemen or Nigeria” could use their experience on UK streets, [...]
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Lone wolf terror threat warning
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Alaskan held in terrorist threats
Homeland Security News - Tue, 02/07/2012 - 12:08
Alaskan man threatened a number of local terrorist acts in an extortion attempt and was arrested by Alaska State Troopers Monday, police said. The man allegedly planned acts of terrorism that, according to police, would have affected oil companies, credit card companies, cellphone companies, the University of Alaska and Alaska State Troopers. Read More This [...]
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Alaskan held in terrorist threats
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Al-Qaeda bid for Brit girl bombers
Homeland Security News - Tue, 02/07/2012 - 12:06
al Qaeda is trying to recruit women to carry out suicide bombings in the UK, MPs warn today. It is using extremist websites to radicalise the angels of death, says their chilling report.The Commons home affairs committee says it has heard evidence the terror group is “specifically launching and targeting women for violent acts”. Read [...]
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Al-Qaeda bid for Brit girl bombers
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Food protein-induced enterocolitis syndrome as a cause for infant hypotension.
Michael R. Greenberg, Ph.D. - Tue, 02/07/2012 - 03:00
Food protein-induced enterocolitis syndrome as a cause for infant hypotension.
West J Emerg Med. 2011 Nov;12(4):512-4
Authors: Coates RW, Weaver KR, Lloyd R, Ceccacci N, Greenberg MR
Abstract
Infants with food protein-induced enterocolitis syndrome (FPIES) may present to the emergency department (ED) with vomiting and hypotension. A previously healthy, 5-month-old male presented with vomiting and hypotension 2 to 3 hours after eating squash. The patient was resuscitated with intravenous fluids, antibiotics, and admitted for presumed sepsis. No source of infection was ever found and the patient was discharged. The patient returned 8 days later with the same symptoms after eating sweet potatoes; the diagnosis of FPIES was made during this admission. Two additional ED visits occurred requiring hydration after new food exposure. FPIES should be considered in infants presenting with gastrointestinal complaints and hypotension. A dietary history, including if a new food has been introduced in the last few hours, may help facilitate earlier recognition of the syndrome.
PMID: 22224148 [PubMed - in process]
Categories: Publications from UCDPER Members
Exposure science and the exposome: an opportunity for coherence in the environmental health sciences.
Paul J. Lioy, Ph.D. - Tue, 02/07/2012 - 03:00
Exposure science and the exposome: an opportunity for coherence in the environmental health sciences.
Environ Health Perspect. 2011 Nov;119(11):A466-7
Authors: Lioy PJ, Rappaport SM
PMID: 22171373 [PubMed - in process]
Categories: Publications from UCDPER Members
Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4.
Jeffrey D. Laskin, Ph.D. - Tue, 02/07/2012 - 03:00
Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4.
Exp Mol Pathol. 2012 Jan 24;
Authors: Connor AJ, Laskin JD, Laskin DL
Abstract
Inhalation of toxic doses of ozone is associated with a sterile inflammatory response characterized by an accumulation of macrophages in the lower lung which are activated to release cytotoxic/proinflammatory mediators that contribute to tissue injury. Toll-like receptor 4 (TLR4) is a pattern recognition receptor present on macrophages that has been implicated in sterile inflammatory responses. In the present studies we used TLR4 mutant C3H/HeJ mice to analyze the role of TLR4 in ozone-induced lung injury, oxidative stress and inflammation. Acute exposure of control C3H/HeOuJ mice to ozone (0.8ppm for 3h) resulted in increases in bronchoalveolar lavage (BAL) lipocalin 24p3 and 4-hydroxynonenal modified protein, markers of oxidative stress and lipid peroxidation. This was correlated with increases in BAL protein, as well as numbers of alveolar macrophages. Levels of surfactant protein-D, a pulmonary collectin known to regulate macrophage inflammatory responses also increased in BAL following ozone inhalation. Ozone inhalation was associated with classical macrophage activation, as measured by increased NF-κB binding activity and expression of TNFα mRNA. The observation that these responses to ozone were not evident in TLR4 mutant C3H/HeJ mice demonstrates that functional TLR4 contributes to ozone-induced sterile inflammation and macrophage activation.
PMID: 22300504 [PubMed - as supplied by publisher]
Categories: Publications from UCDPER Members
Internet Is A Fertile Breeding Ground For Terrorism – UK
Homeland Security News - Mon, 02/06/2012 - 18:48
The internet has become the most significant vehicle in promoting extremism, according to a report released by the Home Affairs Committee. The report says the internet has become a “fertile breeding ground” for terror and is more involved in radicalisation than prisons, universities or places of worship. MPs spoke to radical cleric Abu Hamza who [...]
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Internet Is A Fertile Breeding Ground For Terrorism – UK
Categories: Homeland Security News
Terror group ‘planned for future’
Homeland Security News - Mon, 02/06/2012 - 18:46
A group of UK-based radical Islamists decided against carrying out suicide attacks in London so they would have a “long-term future” in committing acts of terrorism, a court has heard. Within weeks of joining together, the al Qaida-inspired extremists plotted to bomb the London Stock Exchange and to organise for Britons to undergo terrorist training [...]
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Terror group ‘planned for future’
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Philippine extremist planning attacks when killed
Homeland Security News - Mon, 02/06/2012 - 18:43
A key Abu Sayyaf commander killed in a US-backed airstrike in the southern Philippines was planning terror attacks, including new kidnappings of foreigners and bombings, when he was slain, security officials said Sunday. The pre-dawn military bombing offensive on Thursday killed longtime Abu Sayyaf commander Umbra Jumdail and several other militants while they slept in [...]
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Philippine extremist planning attacks when killed
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Thallium-201 for Cardiac Stress Tests: Residual Radioactivity Worries Patients and Security
Environmental/Disaster News - Mon, 02/06/2012 - 03:00
The Journal of Emergency Medicine
Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage.
Jeffrey D. Laskin, Ph.D. - Sat, 02/04/2012 - 03:00
Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage.
Exp Mol Pathol. 2011 Oct;91(2):515-27
Authors: Joseph LB, Gerecke DR, Heck DE, Black AT, Sinko PJ, Cervelli JA, Casillas RP, Babin MC, Laskin DL, Laskin JD
Abstract
Sulfur mustard (SM, bis(2-chloroethyl)sulfide) is a bifunctional alkylating agent that causes dermal inflammation, edema and blistering. To investigate the pathogenesis of SM-induced injury, we used a vapor cup model which provides an occlusive environment in which SM is in constant contact with the skin. The dorsal skin of SKH-1 hairless mice was exposed to saturated SM vapor or air control. Histopathological changes, inflammatory markers and DNA damage were analyzed 1-14 days later. After 1 day, SM caused epidermal thinning, stratum corneum shedding, basal cell karyolysis, hemorrhage and macrophage and neutrophil accumulation in the dermis. Cleaved caspase-3 and phosphorylated histone 2A.X (phospho-H2A.X), markers of apoptosis and DNA damage, respectively, were increased whereas proliferating cell nuclear antigen (PCNA) was down-regulated after SM exposure. By 3 days, epithelial cell hypertrophy, edema, parakeratosis and loss of epidermal structures were noted. Enzymes generating pro-inflammatory mediators including myeloperoxidase and cyclooxygenase-2 were upregulated. After 7 days, keratin-10, a differentiation marker, was evident in the stratum corneum. This was associated with an underlying eschar, as neoepidermis began to migrate at the wound edges. Trichrome staining revealed increased collagen deposition in the dermis. PCNA expression in the epidermis was correlated with hyperplasia, hyperkeratosis, and parakeratosis. By 14 days, there was epidermal regeneration with extensive hyperplasia, and reduced expression of cleaved caspase-3, cyclooxygenase-2 and phospho-H2A.X. These findings are consistent with the pathophysiology of SM-induced skin injury in humans suggesting that the hairless mouse can be used to investigate the dermatoxicity of vesicants and the potential efficacy of countermeasures.
PMID: 21672537 [PubMed - indexed for MEDLINE]
Categories: Publications from UCDPER Members
Woman Charged In Beheading Plot Held Without Bond
Homeland Security News - Fri, 02/03/2012 - 17:35
A federal judge in North Carolina ruled Friday that a Raleigh school administrator accused of paying a hit man to behead three witnesses in a terrorism case should be held without bond until her trial. Nevine Aly Elshiekh made her first court appearance Friday after being arrested last month after FBI agents tracked her to [...]
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Woman Charged In Beheading Plot Held Without Bond
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Notifiable Diseases and Mortality Tables
CDC Morbidity and Mortality Weekly Report - Fri, 02/03/2012 - 16:59
Categories: Government Agency News
Recommended Adult Immunization Schedule — United States, 2012
CDC Morbidity and Mortality Weekly Report - Fri, 02/03/2012 - 16:58
Categories: Government Agency News
QuickStats: Rate* of Nonfatal, Medically Consulted Fall Injury Episodes,† by Age Group
CDC Morbidity and Mortality Weekly Report - Fri, 02/03/2012 - 16:58
Categories: Government Agency News
Errata: Vol. 60, No. 48
CDC Morbidity and Mortality Weekly Report - Fri, 02/03/2012 - 16:57
Categories: Government Agency News
